Yazar "Haupt, Matteo" için listeleme
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CCL11 differentially affects post-stroke brain injury and neuroregeneration in mice depending on age
Lieschke, Simone; Zechmeister, Bozena; Haupt, Matteo; Zheng, Xuan; Jin, Fengyan; Hein, Katharina; Weber, Martin S.; Hermann, Dirk M.; Bähr, Mathias; Kılıç, Ertuğrul; Doeppner, Thorsten R. (MDPI, 2020)CCL11 has recently been shown to differentially affect cell survival under various pathological conditions including stroke. Indeed, CCL11 promotes neuroregeneration in neonatal stroke mice. The impact of CCL11 on the adult ... -
Lithium modulates miR-1906 levels of mesenchymal stem cell-derived extracellular vesicles contributing to poststroke neuroprotection by toll-like receptor 4 regulation
Haupt, Matteo; Zheng, Xuan; Kuang, Yaoyun; Lieschke, Simone; Janssen, Lisa; Bosche, Bert; Jin, Fengyan; Hein, Katharina; Kılıç, Ertuğrul; Venkataramani, Vivek; Hermann, Dirk M.; Bahr, Mathias; Doeppner, Thorsten R. (Wiley, 2021)Lithium is neuroprotective in preclinical stroke models. In addition to that, poststroke neuroregeneration is stimulated upon transplantation of mesenchymal stem cells (MSCs). Preconditioning of MSCs with lithium further ... -
Neural progenitor cell-derived extracellular vesicles enhance blood-brain barrier integrity by NF-kappa B (Nuclear Factor-kappa B)-dependent regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in stroke mice
Zhang, Lin; Graf, Irina; Kuang, Yaoyun; Zheng, Xuan; Haupt, Matteo; Majid, Arshad; Kılıç, Ertuğrul; Hermann, Dirk M.; Psychogios, Marios-Nikos; Weber, Martin S.; Ochs, Jasmin; Baehr, Mathias; Doeppner, Thorsten R. (Lippincott Williams & Wilkins, 2021)Objective: Extracellular vesicles (EVs) derived from neural progenitor cells enhance poststroke neurological recovery, albeit the underlying mechanisms remain elusive. Since previous research described an enhanced poststroke ... -
Neuroprotective strategies for ischemic stroke—Future perspectives
Haupt, Matteo; Gerner, Stefan T.; Bähr, Mathias; Doeppner, Thorsten R. (MDPI, 2023)Ischemic stroke is the main cause of death and the most common cause of acquired physical disability worldwide. Recent demographic changes increase the relevance of stroke and its sequelae. The acute treatment for stroke ... -
Preconditioning concepts for the therapeutic use of extracellular vesicles against stroke
Haupt, Matteo; Gerner, Stefan T.; Huttner, Hagen B.; Doeppner, Thorsten Roland (Oxford University Press, 2023)Various preclinical stroke models have demonstrated the neuroprotective effects of extracellular vesicles (EVs) obtained from several types of cells, including neurons, astrocytes, microglia, neuronal progenitor cells, ... -
Quest for quality in translational stroke research––a new dawn for neuroprotection?
Haupt, Matteo; Gerner, Stefan T.; Bähr, Mathias; Doeppner, Thorsten R. (Multidisciplinary Digital Publishing Institute, 2022)Despite tremendous progress in modern‐day stroke therapy, ischemic stroke remains a disease associated with a high socioeconomic burden in industrialized countries. In light of demo-graphic change, these health care costs ...